Staying Lean Without A Diet

Bradford Lowell and colleagues at Harvard Medical School created transgenic mice that specifically lacked the ability to release the inhibitory neurotransmitter GABA in a subset of neurons in the hypothalamus -- the area of the brain important for controlling processes such as hunger, thirst and body temperature. These animals did not become obese despite being put on a high-fat diet, and were also resistant to the effects of an appetite stimulating hormone.

As well as showing that normal energy balance requires inhibitory neurotransmission in the hypothalamus, this study also suggests a possible target for developing drugs for obesity.

Author contact:

Bradford B. Lowell (Harvard Medical School, Boston, MA, USA)
E-mail: blowell@bidmc.harvard.edu

Abstract available online.

(C) Nature Neuroscience press release.

Message posted by: Trevor M. D'Souza