Toronto Western Research Institute
Our lab is interested in cancer initiation (http://vsrp.uhnres.utoronto.ca/Bremner.html). We utilize mouse modeling, together with molecular and genomic strategies to decipher how oncogenic mutations impact distinct cell types in vivo and in vitro. We have exciting new projects on the role of a) Cell competition and b) the Hippo/Warts pathway in tumorigenesis. Our goal is to solve how cells escape the normal constraints of their environment.
If you have a stellar publication record, love solving science puzzles, are ambitious, and your long-term goal is to run your own lab, please email your CV and the contact information of two references (incl. tel. #) to my assistant Ms Julie Wan: email@example.com. Skills in retrovirus and lentivirus generation, fluorescent microscopy, cell culture, live-imaging and RNAi screens are advantages, but excellent cell and molecular ability are the basic requirements. All other things being equal, preference will be given to those who have recently graduated or are about to graduate with a Ph.D., but all outstanding scientists are urged to apply.
Toronto is a vibrant, safe, and multi-cultural city with a world class research community.
A few papers/reviews from the Bremner lab:1. Bremner R and Zacksenhaus E. Cyclins Cdks, E2f, Skp2 and More at the First International RB Tumor Suppressor Meeting. 2010 Cancer Research, 70:6114-8.
2. Chen D, Pacal M, Wenzel P, Knoepfler PS, Leone G, Bremner R 2009 Division and apoptosis of E2f-deficient retinal progenitors. Nature 462: 925-929.3. Chong JL, et al 2009. A Switch of E2F1-3 Function from Activators in Progenitor Cells to Repressors in Differentiating Cells. Nature, 462: 930-934.4. Bremner R (2009). Retinoblastoma: An Inside Job. Cell 137: 992-993.5. Ni Z, Abou El Hassan M, Xu Z, Yu T, Bremner R (2008). The chromatin-remodeling enzyme BRG1 coordinates CIITA induction through many interdependent distal enhancers. Nat Immunol. 9:785-93.
Salary: CIHR level + 5K
Open from: Immediately
Type of employment: Full Time