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NUI Galway, Ireland
Development of novel, biodegradable nanoshells for drug delivery Thesis topic description
The project is funded by Science Foundation Ireland as part of a Strategic Research Cluster of bioscientists, engineers and clinicians involved in developing functional biomaterials for targeted delivery of therapeutics.
The work will entail generation and cell-based screening of combinatorial peptide and antibody libraries using phage display technology. This will be followed by production of antibody fragments in E. coli and characterisation of peptides and fragments in vitro and in a cell-based system. The molecules will be linked to biodegradable nanoshells, containing protein- or DNA-based therapeutics, for targeting to specific cell types for the treatment of disc degeneration disease. Description of Institution and host laboratory
NUI Galway is a thriving institution with over 15,000 students located on the west coast of Ireland. It has established itself as the leading Irish institution in the field of biomaterials and bioengineering. It has a track record of high-level interdisciplinary research in areas such as biomedical engineering, infections disease, cancer biology and molecular diagnostics.
The host laboratory has considerable expertise in recombinant protein production technologies, incorporating E. coli, P. pastoris and cell-free systems. It has received extensive funding for its work in protein production studies, targeted tumour therapy, and immunosensor development, in particular. www.nuigalway.ie/microbiology/dr_gerard_wall.html Requirements A first class or upper second class (2.1) honours BSc, or equivalent, in a biological science. Experience of recombinant protein production in heterologous hosts, particularly E. coli, would be an advantage, as would familiarity with phage display technology. Closing date for applications: July 25th, 2008.
Open from: October 2008
Type of employment: Full Time
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