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Partners In Crime
Scientists have defined the detailed architecture of an enzyme crucial for the replication of two major human viruses.
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Protein Teamwork Underlies Skeleton
Researchers show how mutations in two different proteins can cause osteopetrosis, a rare congenital human disorder.
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It's All In The Expression
Changes in the expression level of certain genes may underlie some of the fundamental differences between humans and chimpanzees.
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Coral Compound Blocks Viruses
A small molecule has been discovered in coral that can be used to block the replication of certain viruses.
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A Murine Model for Human Sepiapterin-Reductase Deficiency
The Sepiapterin reductase gene (SPR) is essential for homeostasis of tetrahydrobiopterin (BH4) and for the normal functions of BH4-dependent enzymes.
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Hemizygosity at the NCF1 Gene in Patients with Williams-Beuren Syndrome Decreases Their Risk of Hypertension
The loss of a functional copy of the NCF1 gene protects a proportion of patients with WBS against hypertension.
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Spread of an Inactive Form of Caspase-12 in Humans Is Due to Recent Positive Selection
The authors suggest that the inactive form of the human caspase-12 gene arose in Africa 100–500 thousand years ago.
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The Power to Detect Disease Associations with Mitochondrial DNA Haplogroups
Scientists used a simulation-based (Monte Carlo) permutation test to generate power curves for European mtDNA haplogroup studies.
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A model for studying cell plasticity in the embryonic microenvironment
Transplanted human metastatic melanoma cells resemble neural crest stem cells in the chick embryo.
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