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Total-Genome Analysis of BRCA1/2-Related Invasive Carcinomas of the Breast Identifies Tumor Stroma as Potential Landscaper for Neoplastic Initiation
Authors postulate that such a genetically unstable stroma might facilitate a microenvironment that may subsequently lead to neoplastic transformation.
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ELMOD2 Is A Candidate Gene For Familial Idiopathic Pulmonary Fibrosis
Research suggests ELMOD2 as a novel candidate gene for susceptibility in familial IPF.
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Human Genomic Deletions Mediated By Recombination Between Alu Elements
Scientists compare the reference human and chimpanzee genomes to determine the magnitude of this recombination process in the human lineage.
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Promoter Mutations That Increase Amyloid Precursor-Protein Expression Are Associated with Alzheimer Disease
The present study provides evidence that Amyloid Precursor-Protein (APP)-promoter mutations that significantly increase APP expression levels are associated with Alzheimer disease.
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Diabetes Gene At Root Of Wider Syndrome
Study shows that some of the 'Gain of function' gene mutations associated with neonatal diabetes mutations can cause a syndrome that can include developmental delay, epilepsy and muscle weakness.
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Old Drug, New Target
Scientists have identified a new target for an old drug that has been used to treat tuberculosis for over 50 years
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Better Digs Benefit Behavior: New Neurons Not Required
A new study fails to find a causal relationship between behavioral improvements and increased neurogenesis in adult mice.
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Sensing Bacterial Infection
New information on the complex interplay between host cells and bacteria during infection is reported.
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Common Genetic Variant Associated With Prostate Cancer
A common genetic marker that is found more frequently in men with prostate cancer than those without is reported in a study.
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Nuclear Protein Controls Virus Invasion
A protein in the cell's nuclear membrane regulates the ability of the HIV virus to invade human cells.
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Parkinson's Gene Cripples Mitochondria
Two teams of scientists reveal that a mutant protein implicated in inherited Parkinson's disease disables the cell's mitochondria.
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LOX Stops The Spread
Scientists identify a protein vital for metastasis that could be a new target for cancer therapies.
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Not Without Risk
A gene-therapy treatment for a severe immune deficiency could contribute to the later development of T-cell lymphomas.
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Creation of Targeted Nanoparticles
Multifunctional nanoparticles, formed via polymerization, offer a new approach to delivering anticancer drugs with a high degree of specificity.
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