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Imatinib Could Cause Tumour Regression
The first targeted anticancer drug to specifically inhibit an enzyme that causes cancer cell growth might also promote tumour regression.
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The Connectivity Map Of Multi-Drug Combinations
The response to drug combinations critically depends on how their biological targets are connected.
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New Way Of Targeting Gene To Treat Breast Cancer
A new way of targeting the PARP1 gene in order to induce cell death in breast cancer cells is reported.
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X-Linked Adrenoleukodystrophy - Newborn Screening And Lorenzo's Oil
Promising methods of screening for and treating X-linked adrenoleukodystrophy (X-ALD) are highlighted.
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Potential Therapeutic Target In Down Syndrome
Blocking the actions of an inhibitory neurotransmitter can improve performance in several memory tasks in a mouse model of Down syndrome.
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Proteins A La Carte
A method to incorporate non-naturally occurring amino acids into proteins in mammalian cells is described.
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Genomic Marker For Lung Cancer
Gene expression patterns in lung airway cells from smokers may aid the early detection of lung cancer.
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A Natural Barrier To HIV Transmission
A protein in one of the first immune cells encountered by HIV as it enters the body acts as a natural barrier to transmission of the virus.
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New Immune Cell Exit Strategy
Immune cells recruited to sites of infection can use more than one type of molecule to exit the bloodstream.
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Mitochondrial Point Mutations Do Not Limit Lifespan
A large number of point mutations in mitochondria do not have a direct link to the ageing process in mice.
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Genetic Variant Protects Against Four Infectious Diseases
A genetic variant associated with protection against four different infectious diseases is described.
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Genetic Variant Associated With Triglyceride Levels
Scientists have identified a rare genetic variant that is associated with lower levels of triglycerides.
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Tumour Suppressor Linked To Heart Failure?
Inhibition of angiogenesis by the tumour suppressor protein p53 may have a critical role in the progression of cardiac hypertrophy to cardiac failure.
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New Role For Gut-Lining Cells?
Intestinal epithelial cells may have a key role in shaping the function of immune cells.
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