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Whole Genome Association Reveals Schizophrenia Gene
A genetic basis for schizophrenia found on both the X and Y chromosomes, is presented.
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A Potential Therapeutic Agent For Retinoblastoma
A natural agent derived from the bark of the South-American lapacho tree inhibits growth and induces cell death in human retinoblastoma cell lines.
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Novel Pathway For Antibiotics-induced Cell Death
Scientists have identified unforeseen mechanisms by which quinolones - a family of broad-spectrum antibiotics among the most widely prescribed - induce bacterial cell death.
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Green Tea May Help To Fight Lung Cancer
A possible mechanism for green tea's anticancer activities is reported.
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Laying Sleeping Sickness To Rest
The parasite that leads to sleeping sickness can be lulled to sleep itself using a newly discovered pathway.
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Jumonji Family Removing The Mark
Two papers identify a sought-after regulator of 'marks' on the chromatin that are associated with whether the genes are switched on or off.
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How Stress Causes Anxiety In Adolescent Mice
Stress may cause anxiety in adolescents due to an atypical response to a neurosteroid.
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A Cheap Alternative For Large Scale RNA Interference Screens
A cost-effective resource for RNA interference (RNAi) that allows the effective reduction of gene expression is presented.
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Bacteria-mediated Immune System Paralysis
How the pathogen Staphylococcus aureus, a leading cause of hospital-related infections, disables the immune system is described.
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Understanding Cancer Spread
A signalling pathway that enhances the formation of metastases in a mouse model of prostate cancer has been identified.
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Cancer Genomes Probed
Biologists have sequenced over 500 protein kinase genes found in 210 diverse human cancers and identified over 1,000 different mutations.
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Transcription Factor SIX5 Is Mutated In Patients With Branchio-Oto-Renal Syndrome
Study identified heterozygous mutations in the second member of the SIX family of proteins, unc-39 (SIX5), as a novel cause of Branchio-oto-renal syndrome.
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Most Rare Missense Alleles Are Deleterious In Humans
Results imply that mutation-selection balance may be a feasible evolutionary mechanism underlying some common diseases.
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Kalirin Gene: A Novel Candidate Gene For Coronary Artery Disease
Data suggest the importance of the KALRN gene and the Rho GTPase–signaling pathway in the pathogenesis of Coronary Artery Disease.
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Gene Therapy Progress And Prospects: Ultrasound For Gene Transfer
Ultrasound exposure in the presence of microbubbles (MCB) increases plasmid transfection efficiency in vitro by several orders of magnitude.
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Sotos Syndrome
The NSD1 mutational spectrum has been defined, the phenotype of Sotos syndrome clarified and diagnostic and management guidelines developed.
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Evidence Of A Spinal Motor Neuron Neurotrophic Factor
Pleiotrophin, or heparin binding neurotrophic factor, promotes regeneration of peripheral nerve axons after sciatic nerve transaction.
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