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Mapping and Cloning Genes - Goodbye to All That?
A paper describing the use of whole-genome deep sequencing to pinpoint mutations in the worm C. elegans is published; in principle, this approach be applicable to any model organism whose genome has been sequenced.
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Sex in Bacteria for Genome-wide Interaction Screens
Two papers describing techniques for genome-wide genetic interaction screens in bacteria are published.
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Pre-eclampsia May be an Autoimmune Disease
A pre-eclampsia-like syndrome can be induced in mice by giving them autoantibodies isolated from humans with the disease.
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A Great Warm-up Act
Promoting blood vessel growth and tissue remodelling may improve outcome in patients with muscular dystrophy.
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Avoiding Attack When Not Stressed
A study explains the process how healthy cells express a panel of microRNAs that help avoid unwanted recognition and attack from the immune system., and suggests the same mechanism may also help tumours to go undetected.
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Mediating Restraint
Scientists report that a molecule called CD200R exerts a dampening effect on specific immune cells residing in the lung.
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Research Agenda for Personalized Genomics
A multifaceted research agenda is urgently needed to reap the full benefits and avoid the potential pitfalls of personalized genomics.
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Enzyme Implicated in Restless Legs Syndrome
A new genetic variant has been implicated in risk of restless legs syndrome.
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Unlocking the Door to HIV Infection
The structure of the protein complex responsible for unlocking cells to enable HIV entry is reported.
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The Impact of microRNA on Proteins
The consequences of protein regulation by microRNAs (miRNAs) are studied on a large scale in two papers.
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Genetics for Mental Health Disorder
Specific human genomic variations associated with schizophrenia are identified by three research groups.
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Family History of Pancreatic Cancer in a High-Risk Cancer Clinic: Implications for Risk Assessment
A case-control design was used to investigate the importance of a family history of pancreatic cancer (PC) to cancer risk assessment.
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Health Behaviors and Psychological Distress in Women Initiating BRCA1/2 Genetic Testing: Comparison with Control Population
Study looked at breast cancer screening practices, lifestyle behaviors and psychological distress among 640 women initiating BRCA1/2 testing.
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