posted 04-19-2012 07:55 PM            

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AnaSpec, EGT Group is pleased to announce the release of three antibodies (two monoclonal and one polyclonal) against FXYD2γa. FXYD2γa is a regulating subunit of the NA+-K+-ATPase and has been identified as a unique and specific pancreatic beta cell surface biomarker. In individuals with Type 1 diabetes or in pancreatic sections of streptozotocin-treated Macacus cynomolgus monkeys, loss of FXYD2γa has been closely correlated with a loss of insulin positive cells.1
Anti-hFXYD2γa antibodies are purified antibodies reacting with an 11 amino acid residue peptide of FXYD2γa. Monoclonal anti-FXYD2γa antibodies from Clone 4F9G9 show high specificity towards FXYD2γa beta-cell biomarker while monoclonal anti-FXYD2γa antibodies from Clone 3C1D10 show high sensitivity towards FXYD2γa beta-cell biomarker. A rabbit polyclonal anti-hFXYD2γa antibody is also available. These antibodies can be used for beta cell specific targeting and non-invasive imaging. The use of targeting strategies against the biomarker (FXYD2γa) allows early identification of beta cell and the follow up of therapies for diabetes patients.
Reference
1. Flamez, D. et al. Diabetologia. 2010 Jul.53(7):1372-83.

Eurogentec has an exclusive license under patent n° WO2009/101181 A2. Use of this product employs the following patent rights exclusively licensed to Eurogentec S.A. : (a) any claims issuing from the following Patent Applications Serial Nos. 9710674,4, 12/735,731 and 2010-546352 and (b) all patents to be issued pursuant thereto, and all continuations, continuations-in-part, reissues, substitutes, and extensions thereof. The purchase of this product includes a limited, non-transferable immunity from suit under the foregoing patent claims for using only this amount of product for the purchaser's own internal research. No right under any other patent claim and no right to perform commercial services of any kind, including without limitation reporting the results of purchaser's activities for a fee or other commercial consideration, is conveyed expressly, by implication, or by estoppel. This product is for research use only. Diagnostic uses under these patents require a separate license from Eurogentec S.A.
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