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registry of biomedical companies

July 26, 2026

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Registry of biomedical companies:

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Dye Gel Tagged Electroseparation (DGTE) (and Non-Gel) Info Enterprises Canada

POCO
Colombie-Britannique (C.-B.) V3B 1G3
Canada
Toll free: +011-2369836419

Phone: +011-236-983-6419
Fax: 1-604-941-9022
E-Mail: This e-mail address is being protected from spam bots, you need JavaScript enabled to view it

Description:

We are in the process of consulting future licensing manufacturers for subsidiaries.

We are gathering business intelligence in the USA for our "Digitel Laser Device" to be developed with Canadian & Philippine manufacturing subsidiaries. A partner in Canada with exclusive rights to use the dye tag is planned and another in DGTE City (NIR), the PHIL. (see: JLG Info Enterprises).

We will contact candidates to be licensed exclusively with use of our dye-tagged denaturing electrophoretic protocol using microcapillary non-gel columns for hi-throughput, hi-speed proteomic and peptide analysis as well as gel electrophoresis for more larger samples more limited runs which beats the competition for fast turn around of our column runs with faster, ease of use not available to conventional dyed in gel protocols.

The denatured analytes with attached dye-tags will be isoelectric focused by an electric field gradient along the cartridge of loaded sample multiple non-gel capillaries or larger sample gel columns, separation being based on size/MW and net charge for each protein type analyte.

The feature of running parallel samples (x2), one with denaturing dye-tag and the other with no dye added will allow prep recovery of the sample in question of interest in this type of analysis.

In the long term of interest to our particular independently run Philippine-based subsidiary in DGTE City (NIR), the PHIL. is to use our digitel reader and for marketing and capitalization of company facilities with exclusive licensing for the dye tag (DT) reagent product which also will be manufactured multinationally and with licensed establish chemical cos. especially in the U.S. of A.

The competition we expect or believe are going to field similar analytical machines with laser-driven reading capability without a dye-tag and will rely on less quantitave methods to read analytical peaks and using a universal method of mechanically collecting aliquots that are resolvable by titre and d. But without quantitative capability it is less elegant and automated for routine quantitation for QC analysis runs as in food sciences & technology industry protocols for such food-grade analytes creating extra market share for our product.

In both the competition's device or reader conventional protocol and our own DT with protocol the reader will have to be cost-effective to compete successfully in the very fast-growing and lucrative bioinformatics field and metabolomics field which is just beginning with proteomics and its genomics fields.

There has been mention of prioritizing the bioinformatics-led development of the Direct Applied RNA-Based Regulatory (DARR) protocols led by the inventions from research at the U. of Warsaw, Poland by J. Trylska's and group using the fine biologic PNA-B12 with Vit B12 as the carrier through cellular introduction and in our case a new candidate proprietarily protected here on this website called PNA-K2 with Vit K2 as the carrier and with linker/spacer as the carrier attached to the regulatory moiety of the fine biologic in its macromolecular structure. At Skye Blue, the author and believes that A-prioritization should occur with the development of applications with problems for forage cropping, microbial probiotics, microbial feed additive prebiotics and large animal metabolism in livestock production models, the latter which is believed to be extensive with animal nutrition, health and animal welfare.

In the news: [The reader is invited to research the Internet for more of the same news reported here. Including recent reports of what is called a Maurice Flex Cartridges(R)].

Thermo-Fisher Scientific Ltd. (R) could be an interested co-licensee in this new endeavor in electroseparation.

Bio-Rad® is also another potential co-licensee with their “Substrate-Level” Chromophore Tagged (“Dyed”) Protein PAGE and Mini-Protein Reader in the competition. Note this is also a viable alternative to our method.

Amersham(R) Australia was also approached earlier as a first choice for developing the dye-tag reagent. We will try them again in Australia.

We have found that our electrophoretic technology will change denaturing PAGE due to its facility in the laboratory including semi-automated prep work. We are also proposing isoelectric non-gel prep separation as another option for use in analysis.

Computational analytics will predominate with proteomics with the [LMW]-proteome from secretalogue body fluids or blood plasma, clean fermentation sampling for food-related products, biopharma, hormones, enzymes, nutraceuticals (non-secondary alkaloids), antibodies for immuno analysis and the multiplicity of biomarker research in metabolimics and health.

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FIG. 1. Theoretical Schema for Synthesis of Dye-Tagged Azo-Ene Sulfonic Detergent for Electroseparation of Proteins by MW/Length:

1. Starting material - dodecylcarboxylic acid

CH3-(CH)10-COOH

2. alpha-halogenation with Br2(g)

CH3-(CH)9-CH(Br)-COOH

3. elimination of HBr

CH3-(CH)9-CH=CH-COOH

4. splitting of the double bond with amine formation

CH3-(CH)9-CH-NH2 NH2-CH2-C(O)-NH2

5. azo group (chromophore) formation with elimination between the N twice

CH3-(CH)8-CH2-N=N-CH2-C(O)-NH2

6. acid-catalyzed elimination of H2O

CH3-(CH)8-CH2-N=N-CH=CH-NH2

7. nucleophilic attack of -NH2 grp. for sulfonate grp.

CH3-(CH)8-CH2-N=N-CH=CH-SO3H

PRODUCT: Azo(delta3)-ene(delta1)-dodecyl-sulfonate as the dye-detergent reagent that is expected to stack well on our PAGE-column.

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FIG. 2. Practical Schema Using Hydrazine (NH2-NH2) Chemistry to Variate the Chemical Structure of Our Molecular Reagent with Only 1 Methylene Group Between the Azo Unsaturation and the Sulfonate Group with a Total of 12-C Length in its Side-chain.

1. Starting material is Undecanoic Acid.

CH3(CH)n=9-COOH

2. Reduction of the Carboxyllic acid to the Aldehyde.

CH3(CH2)n=9-CHO

3. Alpha-Bromination.

CH3-(CH2)n=8-CH(Br)-CHO

4. Adduct formation with the Hydrazide to the Ene-Azo-Amine.

CH3-(CH2)n=8-CH=CH-N=N-CH2-NH2

(Note: Bi-product of the Ene-Amine-Hydrazide.)

5. Formation of the Ene-Azo-2-Methyl-thio-pyridinium Nitrate via 2-Thiomethylpyrdinium Nitrate.

CH3-(CH2)n=8-CH=CH-N=N-CH2-2-Methylthiopyridinium(+)NO3(-)

6. Sulfate Formation with Cl(SO3)H