home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> mail archive   |   Search register for news alert (free)  
  Carlo Gambacorti: DIAG: PT.REQ(Alport S.)/ Intracytoplasmic sperm injection  

archive of HUM-MOLGEN mails


[Author Prev][Author Next][Thread Prev][Thread Next][Author Index][Topic Index]

To: Multiple recipients of list HUM-MOLGEN <HUM-MOLGEN@NIC.SURFNET.NL>
Subject: DIAG: PT.REQ(Alport S.)/ Intracytoplasmic sperm injection
From: Carlo Gambacorti <GAMBACORTI@icil64.cilea.it>
Date: Fri, 27 Oct 1995 08:58:36 MET-DST

           HUM-MOLGEN  DIAGnostics/Clinical Research

This DIAG message contains 1 submessage(s):


2)      intracytoplasmic sperm injection (ICSI)

  Carlo Gambacorti MD, Editor,
  Human Molecular Genetics network
  Diagnostics/Clinical Research Section


Five members of our family are hit by the alport-syndrom.
Do there are any new realizations except the


Apparent family location: Germany


At the recent Andrology in the Nineties conference in Belgium there was much
debate about the use of intracytoplasmic sperm injection (ICSI) from
oligoasthenozoospermic (OAT) men and genetic risk.  Peter Vogt reported on
the increased incidence of Y-chromosome delections and sex chromosome
anomalies in such men, and there seems to be evidence of a general increase
of paternally inherited anomalies in offspring (see also the somewhat
restricted series for women of advanced maternal age reported by In't Veld
in Lancet 346: 773, 1995).

While the excellent data from the Brussels group reported by Van
Steirteghem does not give rise to urgent concern,   Moosani et al (
Fertility & Sterility 1995 64(4):811-817)  in an analysis of sperm nuclei
by fluorescence in situ hybridization report a significant increase in the
frequency of disomy for chromosome I and XY disomy for infertile men.

The take-home message is that any AOT men and their partners seeking ICSI
for infertility should be given rigorous genetic counselling and advice
about the possible consequences, especially for male offspring.   Screening
for satellite deletions in the AZF region of the Y chromosome should be
mandatory IMHO.

In Belgium now 1% of all births arise from some form of assisted
reproductive technology, and this is likely to rise, according to Frank
Comhaire.   If we assume that the incidence of infertility is 10-15% and
that now nearly all cases can be "treated" by ICSI it is logical to assume
that a similar proportion of all births will result.  Even if only 10% of
OAT men carry a risk of genetic abormality this is still a highly
disturbing scenario for the next generation.  These conditions can *only*
be transmitted iatrogenically - unlike diabetes, for example, where couples
have the choice of reproducing or not reproducing.   With the incredible
acceleration of ICSI into the "run of the mill" IVF clinics without access
to intensive genetic and paediatric services the long-term implications for
health care costs makes the low-birthweight problems of conventional IVF
babies look almost trivial.

Alarm bells are ringing, I'm afraid.

Jim Cummins

Associate Professor in Veterinary Anatomy
Murdoch University, Western Australia 6150
Tel +61-9-360 2668, Fax +61-9-310 4144
E mail <cummins@possum.murdoch.edu.au>
URL <http://Numbat.murdoch.edu.au/spermatology/spermhp.html>

home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap

Mail converted by MHonArc 2.4.4
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 1995-2001 HUM-MOLGEN. All rights reserved. Liability and Copyright.