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To: Multiple recipients of list HUM-MOLGEN <HUM-MOLGEN@NIC.SURFNET.NL>
Subject: NEWS: in Bioscience and Medicine
From: "Bergen (ioi)" <A.A.BERGEN@AMC.UVA.NL>
Date: Mon, 23 Dec 1996 09:52:53 +0100

         HUM-MOLGEN News in Bioscience and Medicine

News in Bioscience and Medicine:


Summary of recent postings (selection):

2 | GeneCards: a new database integrating information about gene
3 | GDB - What's New
4 | Resources for Molecular Cytogenetics
5 | IXDB - the X chromosome WWW site
6 | How to announce new Internet resources, press releases etc.



WWW:    http://www.ebi.ac.uk/imgt/
E-mail: malik@ebi.ac.uk

Professor Marie-Paule LEFRANC
Laboratoire d'ImmunoGenetique Moleculaire, LIGM
UMR CNRS 9942, Institut de Genetique Moleculaire
BP 5051, 1919 route de Mende, 34033 MONTPELLIER Cedex 1
Telephone: (33) 67 61 36 34
FAX : (33) 67 04 02 31/67 04 02 45
e-mail : lefranc@ligm.crbm.cnrs-mop.fr

The ImMunoGeneTics database, IMGT, is an integrated specialised database
containing nucleotide sequence information of genes important in the function
of the immune system. It collects and annotates sequences belonging to the
immunoglobulin superfamily which are involved in immune recognition, these are
the B cell antigen receptor (Immunoglobulin or Ig), the T cell antigen receptor
(TCR) (LIGM-database) and the class I and class II molecules of the
Human Leucocyte Antigens (HLA) system (HLA-database).

An integrated immumogenetics database (IMGT/LIGM) specialising in Ig and TcR is
under development through collaboration between LIGM, IFG and EMBL oustation
EBI. This database consists of the Ig and TcR sequence entries.

Release 96.11 contains 7937 fully annotated sequence entries.

LIGM Montpellier :Marie-Paule Lefranc (coordinator)
Veronique Giudicelli,Denys Chaume
EMBL-EBI :Ansar Malik
IFG :Werner Mueller

SRS server: http://www.ebi/srs/srsc
NOTE: Selecting this option will bring you to the SRS qerry interface page,
where you have to select "search Sequence Libraries"
WWW server: http://www.ebi.ac.uk/imgt/
FTP server: ftp.ebi.ac.uk/pub/databases/imgt
E_MAIL server: email netserv@ebi.ac.uk -- send "help IMGT" in the mail body.
This database is available on CD-ROM as an acompanying database
to the EMBL Nucleotide Sequence Database at nominal cost.

Ansar Malik Ph.D | Email:Malik@ebi.ac.uk
EBI - European Bioinformatics Institute | URL: http://www.ebi.ac.uk
Hinxton Hall, Hinxton | Tel: +44 (1223) 494417
Cambridge CB10 1RQ, UK | Fax: +44 (1223) 494968


2 | GeneCards: a new database integrating information about gene functions

WWW:    http://bioinfo.weizmann.ac.il/cards/
E-mail: lvrebhan@bioinfo.weizmann.ac.il

This new service presents extracts of the data stored in public databases like
GDB, OMIM and SWISS-PROT with the intention of facilitating a brief overview of
the cellular functions of the products of a gene, the diseases in which
have been found, and much more. For example, see GeneCards for the famous
BRCA1 or TP53 genes.


3 | GDB - What's New

WWW:    http://gdbwww.gdb.org/
E-mail: pfoster@gdb.org

1.Release of Mapview 2.0

Mapview 2 is a Java applet that displays multiple maps with
common markers indicated by alignment lines. Whole maps
or slices can be displayed. Users will have the options of
viewing maps in either Mapview 1 or 2. For help retrieving a
map or maps, see Access Points to GDB.

2.Universal Coordinate Querying

Another option for searching on the basis of location has been
added to the query forms. All Localizations, immediately following
Cytogenetic Localization on the query forms, will use a specified
location to search for Genomic Segments (and its subclasses,
amplimers, genes, clones) across all maps in GDB simultaneously
based on a common coodinate system.

3.Other New Features

The Order attribute of GenomicSegment and its subclasses has
been renamed to Related Segments. The Order class has been renamed
to Relationships between Genomic Segments.
The menus that border the top of the details forms have been reorganized.
When retrieving sequence information from a detail form
(Nucleic Acid Sequences), you will be asked to choose a sequence database,
either GSDB (Genome Sequence Database) or GenBank (at NCBI). This
selection will become your default database for future sequence
retrievals, but you can change your preference at any time.

4.Large Data Sets in GDB (1-Dec-96)

           Source                               Data Type

           Cal Tech                             BAC Library
           Image Consortium                     Clones
           Roswell Park Cancer Institute        PAC Libraries
           Science                              Human Transcript Maps
           Stanford                             Radiation Hybrid Maps
           Whitehead Institute                  Radiation Hybrid Maps
           CHLC                                 Linkage Maps
           Genethon                             Linkage Maps


4 | Resources for Molecular Cytogenetics

WWW:    http://bioserver.uniba.it/fish/rocchi/welcome.html
E-mail: rocchi@area.ba.cnr.it

We built up a new Web site on Molecular Cytogenetic Resources.
Most of them are partial chromosome paints derived from somatic cell
hybrids. They are free available to the scientific community. This is the
Web address:


Mariano Rocchi


5 | IXDB - the X chromosome WWW site

WWW:    http://www.mpimg-berlin-dahlem.mpg.de/~xteam/
E-mail: leser@mpimg-berlin-dahlem.mpg.de

The Max-Planck-Institute for Molecular Genetics in Berlin, Germany, would like
to announce the availability of IXDB via the WWW.
IXDB is a new database which stores information related to the physical mapping
of the human X chromosome. It also stores data about genes, maps, contigs and
several clone libraries. A graphical map display will be released soon. Objects
are provided with links to other WWW-databases whereever possible.
Comments and corrections are always welcome.

Ulf Leser


6 | How to announce new Internet resources, press releases etc.

You can announce (free) new Internet resources, press releases etc. at


For other announcements please take a look at



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Phone:  020-566 4598 (The Netherlands), (206) 386-2101 (USA)
Fax:    020-691 6521 (The Netherlands), (206) 386-2555 (USA)

Dr. Arthur A.B. Bergen
Department of Ophthalmogenetics
The Netherlands Ophthalmic Research Institute (IOI)
Royal Academy of Sciences of the Netherlands (KNAW)

** Snail-mail: **           ** FAX: **             ** E-mail: **

P.O.Box 12141               (+31)206916521         A.Bergen@IOI.KNAW.NL
1100 AC  Amsterdam
The Netherlands

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