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To: list@hum-molgen.de
Subject: HUM-MOLGEN News Alert - August 17, 2006
From: FS Zollmann <zollmann@hum-molgen.de>
Date: Thu, 17 Aug 2006 13:25:05 +0200


__________________________________________________________________________

   Cambridge Healthtech Institute's 2nd Annual
   Quantitative PCR, Microarrays and Biological Validation
   October 22 - 24, 2006 | Providence, Rhode Island

   => http://hum-molgen.org/promotion-qPCR

   - Gene expression profiling continues as the predominant tool to identify
     markers associated with disease or therapy targets
   - Gene expression data is prone to variance from experiment to experiment,
     lab to lab, platform to platform
   - Gene expression data must be validated with independent quantitative
     analysis tools
__________________________________________________________________________


INTERNATIONAL COMMUNICATION FORUM IN HUMAN MOLECULAR GENETICS
HUM-MOLGEN News Alert - August 17, 2006 - http://hum-molgen.org


Genetic News
by T.M. D'Souza, S. Chandler, T. Dalaya, K. Markey, J. Mill, La Merie S.L,
R. Nemade, D. Sharma, F.S. Zollmann
http://hum-molgen.org/NewsGen

- Hunt For DNA Amplified In Cancers Uncovers Important Target Gene
    Gene amplification links growth controlling pathway from Drosophila
    to human cancers
    http://hum-molgen.org/NewsGen/08-2006/msg37.html

- Scientists Reverse Evolution
    Half-Billion-Year-Old Gene is Reconstructed from Two Descendants
    http://hum-molgen.org/NewsGen/08-2006/msg36.html

- Linkage Analysis Identifies a Novel Locus for Restless Legs Syndrome
   on Chromosome 2q in a South Tyrolean Population Isolate
    Research report of a genome-wide linkage scan of patients with
    Restless Legs Syndrome assessed in a population isolate of South
    Tyrol (Italy).
    http://hum-molgen.org/NewsGen/08-2006/msg35.html

- Peters Plus Syndrome Is Caused by Mutations in B3GALTL, a Putative
   Glycosyltransferase
    Research show that Peters Plus is a monogenic, primarily
    single-mutation syndrome.
    http://hum-molgen.org/NewsGen/08-2006/msg34.html

- Navajo Neurohepatopathy Is Caused by a Mutation in the MPV17 Gene
    Infantile, childhood, and classic forms of NNH have been described.
    http://hum-molgen.org/NewsGen/08-2006/msg33.html

- New Autosomal Recessive Form of Stickler Syndrome Is Caused by a
   Mutation in the COL9A1 Gene
    Scientists describe a family of Moroccan origin that consists of four
    children with Stickler syndrome, six unaffected children, and two
    unaffected parents who are distant relatives (fifth degree).
    http://hum-molgen.org/NewsGen/08-2006/msg32.html

- Mouse Study Finds That Mutant Enzyme Is Able To Help Protect DNA From
   Damage
    Research has shown that when DNA damage occurs, a key enzyme --
    called ataxia telangiectasia mutated protein, or ATM -- becomes
    activated.
    http://hum-molgen.org/NewsGen/08-2006/msg31.html

- Researchers Discover A Unique Pattern Of Gene Activity That Can
   Predict Liver Cancer Spread
    Researchers have found that a unique pattern of activity for genes in
    cells located in the tissue surrounding a liver tumor can accurately
    predict whether the cancer will spread to other parts of the liver or
    to other parts of the body.
    http://hum-molgen.org/NewsGen/08-2006/msg30.html

- Tumors Use 'Hijacking' Trick To Evade Attack By Immune Cells
    Researchers have identified a potential mechanism by which tumors in
    mice escape attack from antitumor immune cells.
    http://hum-molgen.org/NewsGen/08-2006/msg29.html

- New Findings Offer More Complete View Of Breast Cancer Gene Mutations
   In U.S. Population
    A large study funded by the National Institutes of Health today
    provided the clearest picture yet of the prevalence in the U.S.
    population of mutations in two genes associated with an increased
    risk of breast cancer.
    http://hum-molgen.org/NewsGen/08-2006/msg28.html

- A Potential New Target For Antidepressants
    A potassium channel called TREK1 may represent a new target for
    antidepressant drugs.
    http://hum-molgen.org/NewsGen/08-2006/msg27.html

- High-Resolution Fluorescence Imaging
    Two developments, expanding the potential applications of
    high-resolution fluorescence imaging, are published.
    http://hum-molgen.org/NewsGen/08-2006/msg26.html

- Antiviral Protein Linked To Healthier Lungs
    Failure to produce enough of an antiviral protein called
    interferon-lambda may be linked to increased susceptibility to
    infection with rhinovirus - a common trigger for asthma
    exacerbations.
    http://hum-molgen.org/NewsGen/08-2006/msg25.html

- Blocking Autoimmune Brain Inflammation
    A key factor that controls the development of brain inflammation is
    reported in two studies.
    http://hum-molgen.org/NewsGen/08-2006/msg24.html

- Feeding immunity
    A link between zinc and a critical aspect of normal immune cell
    function is identified.
    http://hum-molgen.org/NewsGen/08-2006/msg23.html

- Fighting Flies
    The first comprehensive molecular analysis of aggressive behavior in
    any laboratory species is reported in a study.
    http://hum-molgen.org/NewsGen/08-2006/msg22.html

- One Recurrent Cause Of Mental Retardation Found
    Three papers describe a recurrent cause of mental retardation, which
    results from the deletion of a large segment of DNA from chromosome
    17.
    http://hum-molgen.org/NewsGen/08-2006/msg21.html

- How Neurons Sprout Like Trees
    Study reveals how some neurons establish and maintain a precise
    tree-like pattern of dendrites, the slim projections that carry
    electrical signals to and from neighbouring cells.
    http://hum-molgen.org/NewsGen/08-2006/msg20.html

- Protein Folding Lost In Translation
    Scientists describe a new mechanism that could underlie certain
    neurodegenerative diseases.
    http://hum-molgen.org/NewsGen/08-2006/msg19.html

- Survival Of The Well-Connected
    The survival of newly formed brain cells in the adult mouse depends
    on the input activity they receive.
    http://hum-molgen.org/NewsGen/08-2006/msg18.html

- Arthritis Drug Helps Debilitating Inflammatory Disease
    A drug called anakinra brings marked improvement for neonatal-onset
    multisystem inflammatory disease.
    http://hum-molgen.org/NewsGen/08-2006/msg17.html

- Imaging Study May Help Point Toward More Effective Smoking Cessation
   Treatments
    PET and MRI Scans show how even small amounts of nicotine can be
    addictive.
    http://hum-molgen.org/NewsGen/08-2006/msg16.html

- Online Interventions as Medically Viable Options for Treatment
    A study has found that an Internet-based intervention program may
    prevent some high risk, college-age women from developing an eating
    disorder.
    http://hum-molgen.org/NewsGen/08-2006/msg15.html

- Experimental Medication Kicks Depression in Hours Instead of Weeks
    Intravenous ketamine has the ability to relieve depression in as
    little as two hours.
    http://hum-molgen.org/NewsGen/08-2006/msg14.html

- Are Air Freshners Hurting our Lungs?
    Chemical compound found in many air fresheners, toilet bowl cleaners,
    mothballs and other deodorizing products, may be harmful to the
    lungs.
    http://hum-molgen.org/NewsGen/08-2006/msg13.html

- Contact Genetic News editors
    WWW: http://hum-molgen.org/editors.html
    E-mail: news@hum-molgen.org


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__________________________________________________________________________

   Cambridge Healthtech Institute's 2nd Annual
   Quantitative PCR, Microarrays and Biological Validation
   October 22 - 24, 2006 | Providence, Rhode Island

   => http://hum-molgen.org/promotion-qPCR

   - Gene expression profiling continues as the predominant tool to identify
     markers associated with disease or therapy targets
   - Gene expression data is prone to variance from experiment to experiment,
     lab to lab, platform to platform
   - Gene expression data must be validated with independent quantitative
     analysis tools

   Biological research is costly - both in time and resources - making the
   careful design and validation of gene expression experiments to generate
   useful data for diagnostics, target identification, screening, and 
genotyping
   applications critical. Researchers are still confronted with difficult
   questions after completing any expression profiling experiment - how to
   validate and standardize the data that has been generated. Learn from
   seasoned and savvy researchers capturing the complete biological story.
__________________________________________________________________________

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| HUM-MOLGEN - http://hum-molgen.org
| (C) 1994-2006





   
 
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