Infection and Immunity
	Oxford University , Oxford, UK 23-24 February 2000
	Emerging and reemerging infections: the epidemiology of the challenge � Recent trends in infectious disease � Socioeconomic factors � Changes in medical practice � Drug resistance � Extrapolations, prognostications � Climate change � Old friends, new enemies Viral enzymes as drug targets � Principles of selective toxicity as applied to viruses � Classes of viral enzymes � Nucleic acid polymerases and their inhibitors � Proteases and their inhibitors � Glycosidases and their inhibitors � Other enzymes as potential targets Breaking and entering: interactions between pathogens and their cellular receptors � Virus attachment proteins and cellular receptors (e.g. HIV, flu, Dengue) � Specificity, affinity and kinetics � Cellular attachment and invasion by bacteria (*e.g. Salmonella,Mycobacterium, Listeria) � Pathogens as cat burglars � Installing better security Drug resistance: the Red Queen's challenge � The beta-lactam paradigm: a constant battle � The biochemical basis for resistance � The power of selection � Cross-resistance and compensating susceptibility � A battle won, the war to be decided: the story of HIV New approaches to antibiotic discovery � Basic principles of antibiotic action - selective toxicity � Finding new targets for antibiotics to work on? � High throughput screening � "Gene-to-Screen" vs. "Active-to-Target" approaches � Lead compound optimization Effector mechanisms in immunity to pathogens � Kinetics and quality of immune responses (Strep vs Mycobactrium; Flu vs HIV) � Non-adaptive immunity (neutrophils, macrophages, NK cells) � Humoral vs Cellular immunity: antigen recognition � Neutralization and opsonization by antibody � Cytolysis by killer T cells (defence and immunopathogenesis) � Cytokine-mediated effects (helper cells, macrophages) Variation in host susceptibility � Evidence for host variation in immune response factors � Molecular genetics and the hunt for susceptibility genes � MHC association in malaria and dengue infections � Molecular basis for immune response variation � Receptor polymorphisms � Polymorphisms in post-entry factors New approaches to vaccine design � How have we developed most of our current vaccines? � So why don�t we have a vaccine for HIV? � What are the particular problems of developing a vaccine for HIV? � How are these challenges being overcome? Working smarter: combinatorial and evolutionary approaches to the discovery of antimicrobials � Combinatorial chemistry � SELEX � Phage-display � The future
	Organized by:	Oxford University
	Invited Speakers:	Dr William James - Sir William Dunn School of Pathology, University of Oxford Prof Jeff Errington - Sir William Dunn School of Pathology, University of Oxford Dr Sarah Rowland-Jones - Christ Church College, University of Oxford Dr E Holmes - Dept. Of Public Health and Primary Health Care, Institute of Health Sciences, University of Oxford
	Deadline for Abstracts:	N/A
	Registration:	Full Fee: five hundred and forty five pounds sterling Group Discount: four hundred and ninety pounds sterling - for more than one registration from an organisation (not available with other discounts) Academic Discount: three hundred and twenty seven pounds sterling - for full time members of academic institutions.
	Email for Requests and Registration:	cpdbio@conted.ox.ac.uk
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