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SYNTHETIC BIOLOGY

 
  January 18, 2013  
     
 


Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
July 30 - August 12, 2013


The goal of synthetic biology is to enable the predictable reprogramming of cells to execute complex physiological activities. It takes inspiration from our ever-expanding ability to measure and perturb biological systems and the philosophical reflections of Schrodinger and Feynman that rational, physical laws can be used to describe and engineer biology to accomplish useful things. However, biological systems are noisy, massively interconnected, and non-linear. The grand challenge for synthetic biology is therefore how to reconcile the desire for a predictable, formalized design process with the inherent ‘squishiness’ of biology.

This course will focus on how the complexity of biological systems, combined with traditional engineering approaches, results in the emergence of new design principles for synthetic biology. In the lab, students will be introduced to the design-build-test cycle, in which libraries of biological parts are composed into larger modules and evaluated using a variety of high-throughput techniques. Students will work in teams to solve challenges introduced by the instructors and learn how bacterial and eukaryotic regulation of all forms – transcriptional, translational, post-translational, and epigenetic – can be used to engineer cells to do useful things. In addition, internationally-recognized invited speakers will give students a broad overview of applications for synthetic biology, including renewable chemical production and therapeutics, and the current state-of-the-art techniques for both bottom-up and top-down design.
Synthetic biology is an inherently interdisciplinary field.

 
 
Organized by: Karmella Haynes, Julius Lucks, David Savage, Jeff Tabor
Invited Speakers:

Additional Faculty

Michelle Chang, University of California Berkeley

Andy Ellington, University of Texas at Austin

Justin Gallivan, Emory University

Daniel Gibson, J. Craig Venter Institute

Michael Jewett, Northwestern University

Eric Klavins, University of Washington

Richard Murray, California Institute of Technology

Pam Silver, Harvard Medical School

Chris Voigt, Massachusetts Institute of Technology

Ron Weiss, Massachusetts Institute of Technology

 
Deadline for Abstracts: March 15, 2013
 
Registration: Apply here
E-mail: meetings@cshl.edu
 
   
 
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