The Jackson Laboratory, Bar Harbor, Maine
July 6 - 9, 2004
Tuesday, July 6th 6:00 pm, Registration and Reception Wednesday, July 7th 7:30 am, Registration Session I: Mouse Haplotype Structure (Chair, Mark Daly, Whitehead Institute) 8:30 am, “The importance of genetic hotspots in mapping QTL” Ken Paigen, Ph.D., The Jackson Laboratory 9:00 am, “In silico mapping-the possibilities and the problems” Tim Wiltshire, Ph.D., Genomics Inst. Of the Novartis Foundation 9:30 am, “Genetic and haplotype diversity in wild derived mouse inbred strains” Fernando Pardo-Manuel de Villena, Ph.D., University of NC School of Medicine 10:00 am, “Applications of the ancestral haplotype patterns in classical inbred strains” Mark Daly, Ph.D., Whitehead Institute Session II: Research Resources and Demos (Roving Session) (Chair, Molly Bogue, The Jackson Laboratory) 11:00 am, “Mouse Phenome Database and other Resources” Molly Bogue, Ph.D., The Jackson Laboratory Session III: Strategies for Finding Quantitative Trait Genes (Chair, Robert Hitzemann, Oregon Health Sciences University) 11:30 am, “From QTL to QTG: Are we getting closer?” Ariel Darvasi, Ph.D., The Hebrew University of Jerusalem 12:00 pm, “Finding QTL genes with integrative genomics” Beverly Paigen, Ph.D., The Jackson Laboratory 1:30 pm, “The genetics of genome-wide gene expression” John Belknap, Ph.D., Portland VA Medical Center 2:00 pm, “The multicross mapping approach to neuropharmacological and behavioral phenotypes” Robert Hitzeman, Ph.D., Oregon Health Sciences University 2:30 pm, “Efficacy of collaborative cross-based recombinant inbred lines for fine-mapping small effect QTLs” William Valdar, Ph.D., Wellcome Trust Centre for Human Genetics 3:00 pm, “QTL reaper: QTL detection with microarray data.” Ken Manly, Ph.D., Roswell Park Cancer Institute Session IV: Gene-Environment Interactions (Chair, William Dietrich, Harvard Medical School) 4:00 pm, “Model systems for pharmacogenomic discovery” James Watters, Ph.D., Washington University of School of Medicine 4:30 pm, “A QTL analysis of iron storage physiology” Angel Custodio, Ph.D., Children's Hospital Boston 5:00 pm, “Genetic control of Listeria monocytogenes infection” Victor Boyartchuk, Ph.D., University of Massachusetts Med School 5:30 pm, “Genetic analysis of innate immunity to infection” William Dietrich, Ph.D., Harvard Medical School 6:00 pm, Reception and poster session Thursday, July 8th Session V: Systems Biology and Complex Traits (Chair, Joe Nadeau, Case Western Reserve University) 8:30 am, “Mixed up mice: Genetic tools for mammalian systems biology” Gary Churchill, Ph.D., The Jackson Laboratory 9:00 am, “Transcriptional and metabolic profiling of homocysteine homeostasis after diet-induced perturbations in genetically distinct inbred strains of mice” Toshimori Kitami, Ph.D., Case Western Reserve University 9:30 am, “Systems analysis of bone fragility” Karl Jepsen, Ph.D., Mount Sinai School of Medicine 10:00 am, TBA Joseph Nadeau, Ph.D., Case Western Reserve University 11:00 am, “Identifying the key drivers of complex traits through the reconstruction of gene networks using gene expression data from segregating mouse populations” Eric Schadt, Ph.D., Rosetta Inpharmatics 11:30 am, “Combinatorial approaches to the identification of transcriptional regulatory networks using microarray, comparative genomic cis-element analyses, and QTL modifier data” Bruce Aronow, Ph.D., University of Cincinnati 12:00 pm, “The mouse genome as a framework for complex trait analysis” Carol Bult, Ph.D., The Jackson Laboratory Session VI: Statistical Analysis Methods (Chair, Gary Churchill, The Jackson Laboratory) 1:30 pm, “Statistical issues in QTL mapping in recombinant inbred lines” Karl Broman, Ph.D., Johns Hopkins University 2:00 pm, “Graphical diagnostics for multiple QTL investigation” Brian Yandell, Ph.D., University of Wisconsin-Madison 2:30 pm, “Bayesian model selection for mapping complex epistatic quantitative trait loci in experimental designs” Nengjun Yi, Ph.D., University of Alabama, Birmingham 3:00 pm, “GenSimXP: an R package for the simulation and analysis of complex traits in experimental populations” Daniel Gaile, Ph.D., Texas A & M University 3:30 pm, Refreshments, Posters and Computer Demos Friday, July 9th Session VII Detecting and mapping cancer modifier genes (Chair, Kent Hunter, National Cancer Institute) 8:30 am, “Genetic and environmental factors contributing to colorectal cancer susceptibility” David Threadgill, Ph.D., University of North Carolina at Chapel Hill 9:00 am, “Epigenetic modifiers of susceptibility to astrocytoma” Karlyne Reilly, Ph.D., NCI at Fredrick 9:30 am, “Identification of Ter, a modifier of germ cell tumor incidence in male mice” Angabin Matin, Ph.D., UT M. D. Anderson Cancer Center 10:30 am, “Petr1 (p16, Cdkn2b) and Petr2 (mTOR, Frap) encode efficiency alleles that act additively to suppress plasmacytomagenesis” Beverly Mock, Ph.D., CCR, NCI 11:00 am , “Using multi-omic technologies to gain insights into mammary tumor metastasis efficiency” Kent Hunter, Ph.D., National Cancer Institute 11:30 am, Posters and Computer Demos (open through afternoon) Session VIII: Strategies in studying complex Traits: a moderated open forum (Chair, Robert Williams, Ph.D., University of Tennessee) 2:00 pm, Objective: to discuss approaches to complex trait analysis using real test datasets submitted by meeting participants Session IX: Round Table Discussion: challenges, goals, outreach, funding strategies (David Threadgill, Ph.D., University of North Carolina at Chapel Hill, Moderator) 4:00 pm, Objective: to identify challenges/roadblocks to complex trait analysis and to formulate group strategies for the near term, particularly with respect to funding paradigms and the development and optimization of new and existing community research resources. End of Meeting
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Invited Speakers:
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Bruce Aronow, Ph.D., University of Cincinnati John K. Belknap, Ph.D., Portland VA Medical Center Molly A. Bogue, Ph.D., The Jackson Laboratory Victor Boyartchuk, Ph.D,, University of Massachusetts Med School Karl W. Broman, Ph.D., Johns Hopkins University Carol Bult, Ph.D., The Jackson Laboratory Gary Churchill, Ph.D., The Jackson Laboratory Angel Custodio, Ph.D., Children's Hospital Boston Mark Daly, Ph.D., Whitehead Institute Ariel Darvasi, Ph.D., The Hebrew University of Jerusalem William F. Dietrich, Ph.D., Harvard Medical School Daniel P. Gaile, Ph.D., Texas A & M University Robert Hitzemann, Ph.D., Oregon Health Sciences University Kent W. Hunter, Ph.D., National Cancer Institute Karl J. Jepsen, Ph.D., Mount Sinai School of Medicine Toshimori Kitami, Ph.D., Case Western Reserve University Kenneth F. Manly, Ph.D., Roswell Park Cancer Institute Angabin Matin, Ph.D., UT M. D. Anderson Cancer Center Beverly A. Mock, Ph.D., CCR, NCI Richard Mott, Ph.D., Wellcome Trust Centre for Human Genetics Joseph Nadeau, Ph.D., Case Western Reserve University Beverly Paigen, Ph.D., The Jackson Laboratory Kenneth Paigen, Ph.D., The Jackson Laboratory Fernando Pardo-Manuel de Villena, Ph.D., University of North Carolina Sch. of Med. Karlyne Reilly, Ph.D., NCI at Fredrick Eric E. Schadt, Ph.D,, Rosetta Inpharmatics David W. Threadgill, Ph.D., University of North Carolina at Chapel Hill James W. Watters, Ph.D., Washington University of School of Medicine Tim Wiltshire, Ph.D., Genomics Inst. Of the Novartis Foundation Brian S. Yandell, Ph.D., University of Wisconsin-Madison Nengjun Yi, Ph.D., University of Alabama, Birmingham
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