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Keystone Symposia, Monterey, California
April 15 - 20, 2007
There is an increasing awareness in the cell death field that apoptosis may not be the only cellular mechanism for programmed cell death. The demonstration that the classical death receptor mediated pro-apoptotic signaling led to necrotic cell death under apoptosis deficient conditions in selective cell types suggests the existence of a cellular mechanism for necrotic cell death. The ability of Bax/Bak double knockout cells to undergo autophagy cell death suggests that autophagy might provide an alternative mechanism of cell death. The ability of caspase inhibitors to induce autophagy cell death in specific cell types suggests that caspases may normally inhibit the activation of alternative cell death pathways. The cell death field is on the verge of major breakthroughs in the identification of alternative cellular mechanisms of cell death. Since this will be the first international meeting emphasizing the mechanisms of non-apoptotic cell death, we intend to provide a historical review as well as the current views of apoptotic vs. non-apoptotic cell death mechanisms by inviting two keynote speakers: Dr. Richard Lockshin, one of the first persons to notice alternative forms of cell death during normal animal development, and Dr. Craig Thompson, a leader in the cell death research. The meeting will have two major objectives. First, evidence will be provided to document the existence of alternative cellular mechanisms of cell death in normal development, cancer and neurodegenerative diseases. Second, invited speakers will provide new insights into the molecular mechanisms of non-apoptotic cell death. In addition to the poster sessions, we will also leave a significant number of speaker slots for new and hot results selected from abstracts submitted. We expect this meeting will have major impacts on the cell death research in general by highlighting the importance of nonapoptotic cell death mechanisms.
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Organized by:
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Junying Yuan, Dale E. Bredesen and Zahra Zakeri |
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Invited Speakers:
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- Eric Baehrecke, University of Maryland Biotechnology Institute
- Marco Bianchi, San Raffaele Scientific Institute
- Dale Bredesen, Buck Institute for Age Research
- Lynda Chin, Dana Farber Cancer Institute
- Barbara Conradt, Dartmouth Medical School
- Valina Dawson, Johns Hopkins School of Medicine
- Vishva Dixit, Genentech, Inc.
- Monica Driscoll, Rutgers University
- Stephen Fesik, Abbott Laboratories
- Pierre Golstein, Centre d'Immunologie de Marseille-Luminy
- Douglas Green, St. Jude Children's Research Hospital
- J. Marie Hardwick, Johns Hopkins University
- Marja Jaattela, Danish Cancer Society
- Adi Kimchi, Weizmann Institute of Science
- Sally Kornbluth, Duke University Medical Center
- Guido Kroemer, Centre National de la Recherche Scientifique
- Michael Lenardo, NIAID, National Institutes of Health
- Beth Levine, University of Texas Southwestern Medical Center
- Richard Lockshin, St. John's University
- Masayuki Miura, Grad. Sch. Pharmaceutical Sci., Univ. Tokyo
- Claudio Soto, University of Texas Medical Branch
- Craig Thompson, Abramson Family Cancer Research Institute, University of Pennsylvania
- Yoshihide Tsujimoto, Osaka University Medical School
- Shaomeng Wang, University of Michigan
- Eileen White, Rutgers University
- Junying Yuan, Harvard Medical School
- Zahra Zakeri, Queens College of City University of New York
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Deadline for Abstracts:
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Dec. 15, 2006
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Registration:
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Please see website
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E-mail:
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info@keystonesymposia.org
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