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A*STAR of Singapore to Launch an Online Publication Promoting its Research
Macmillan Scientific Communications (MSC) and Singapore's Agency for Science, Technology and Research (A*STAR) launch new open access website, A*STAR Research, to highlight some of the best research published by A*STAR's research institutions.
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Understanding Schizophrenia
Dysfunction of neurotransmitter signalling can cause pathological behaviour similar to that seen in schizophrenia.
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The Long Shadows of Adversity
Severe stress suffered at an early age can cause long-lasting changes to gene expression patterns in the mouse brain.
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Damaging DNA from a Distance
Medically used nanoparticles can damage the DNA of cells without crossing cellular barriers in the body.
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Inducible MicroRNA Sponges for Intact Organisms
A method for the tissue-specific inhibition of microRNAs -- which play a key role in regulating gene expression -- is published online.
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Location, Location, Location
A drug that inhibits excitatory activity in the brain can either improve or worsen the progression of Huntington's disease (HD) depending on where on neurons its targets are located.
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Arthritis is Spreading
A mechanism that accounts for the spreading of arthritis between joints is presented in a study.
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Disrupting Lasting Memory
A new protein holds the key to making long-lasting antibody responses in the body.
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Common Genetic Risk Variants for Parkinson's Disease
Two independent studies report that common variants at five genes are risk factors for sporadic Parkinson's disease.
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Exome Sequencing Identifies Cause of Miller Syndrome
Targeted sequencing of the protein-coding regions of the human genome has been used to identify the cause of a rare genetic disorder.
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Variants Associated with Hearing Loss in Children Receiving Chemotherapy Medication
An association between a chemotherapy-induced hearing loss and specific genetic variants has been identified.
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A Deletion is Associated with Neurodevelopmental Problems
A small deletion at a specific region on chromosome 15 is associated with a range of neurodevelopmental problems, including developmental delays and seizures.
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Smoking and Autoimmunity Affect Rheumatoid Arthritis Susceptibility
New insights into the genetic basis of rheumatoid arthritis are reported in two papers.
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Re-Thinking Obesity
Mutations in specific genes fully explain a small but significant subset of patients with obesity and/or type 2 diabetes while genetic factors play a key role in determining susceptibility to both disorders in the broader population.
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Notch Takes a Knocking
A drug that blocks a protein involved in cancer once thought 'un-blockable' has shown promise in a mouse model of leukaemia.
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Speeding Up 'Ethical Stem-Cell' Production
The process of reprogramming mature cells into a stem-cell-like state can be accelerated.
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