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To: Multiple recipients of list HUM-MOLGEN <HUM-MOLGEN@NIC.SURFNET.NL>
Subject: LITE: New: Preview Molecular Medicine
From: Arthur Bergen <bergen@AMC.UVA.NL>
Date: Fri, 16 Jun 1995 15:56:29 +0100

Note from the editor:

As a service to the genetics community from The Picower Institute Press and 
Blackwell Science, HUM-MOLGEN subscribers will receive the TOC preview of the 
Journal  "Molecular Medicine" for FREE under the LITE TOPIC. 
Please find the first six TOCs, including the july 'in press' issue, below.

In general,
We intend to send you no more than than 10 TOC previews (per month), with a 
selection system based on the highest citation index and HUM-MOLGEN 
direct interest score. A number of additional, special interest TOCs will be 
send to you under a specific TOPIC.

Take it LITEly!

Arthur Bergen   

Molecular Medicine


Premier Issue, November 1994

Molecular Medicine: the Future of Biomedical Science and Clinical Practice                                                    1
A. Cerami and K.S. Warren

Gene Therapy: Hopes, Hypes and Hurdles                                                                                                          2
I.M. Verma

In This Issue
Summaries of Articles                                                                                                                                          4

Original Articles
Role of Macrophage Oxidative Burst in the Action of Anthrax Lethat Toxin                                                    7
P. Hanna, B. Kruskal, R.A. Ezekowitz, B. Bloom, and R.J. Collier*

High Prion and PrPSc Levels but Delayed Onset of Disease in Scrapie-Inoculated                                          19 
Mice Heterozygous for a Disrupted PrP Gene
H. Beler, A. Raber, A. Sailer, M. Fischer, A. Aguzzi, and C. Weissmann

Pentoxifylline and Other Protein Kinase C Inhibitors Down-Regulate HIV-LTR                                           31
NF-kB Induced Gene Expression
D.K. Biswas, C.M. Ahlers, B.J. Dezube, and A.B. Pardee

The Evolutionarily Conserved Ribosomal Protein L23 and the Cationic Urease                                            44 
b-Subunit of Yersinia enterocolitica O:3 Belong to the Immunodominant 
Antigens of Yersinia-Triggered Reactive Arthritis
A.K.H. Mertz, A. Daser, M. Skurnik, K. Wiesmller, S. Batsford, J. Braun
P. Wu, H. Appel, A. Distler, and J. Sieper
Submitted by N.A. Mitchison

Clonal Hematopoiesis and Acquired Thalassemia in Common Variable                                                          56
M. Belickova, H.W. Schroeder, Jr., Y.L. Guan, J. Brierre, S. Berney, 
M.D. Cooper, and J.T. Prchal

X Chromosome Inactivation Patterns Correlate with Fetal-Placental Anatomy                                               62
in Monozygotic Twin Pairs: Implications for Immune Relatedness and 
Concordance for Autoimmunity
V. Trejo, C. Derom, A.Vlietinck, W. Ollier, A. Silman, G. Ebers, R. Derom, 
and P.K. Gregersen
Submitted by K.S. Warren

Circulating Fibrocytes Define a New Leukocyte Subpopulation That Mediates                                              71
Tissue Repair
R. Bucala, L. Spiegel, J. Chesney, M. Hogan, and A. Cerami

Glucocerebrosidase Mutations in Gaucher Disease                                                                                           82
E. Beutler, A. Demina, and T. Gelbart

Lipopolysaccharide Signals Activation of Tumor Necrosis Factor Biosynthesis                                             93
through the Ras/Raf-1/MEK/MAPK Pathaway
T.D. Geppert, C.E. Whitehurst, P. Thompson, and B. Beutler
Submitted by A. Cerami

The Molecular Basis of Increased Glomerulosclerosis after Blockade 
of the renin Angiotensin System in Growth Hormone Transgenic Mice		104
E.P. Peten, L.J. Striker, A. Fogo, I. Ichikawa, A. Patel, and G.E. Striker
Submitted by D.K. Peters

Molecular Medicine Database                                                                                                                      116

Instructions for Authors                                                                                                                                117

*Underlining denotes contributing editor.  Molecular Medicine



January 1995

Molecular Medicine Society                                                                                                                             119
D.G. Nathan

Mini Reviews                             
Angiogenesis Inhibitors Generated by Tumors                                                                                               120
J. Folkman

The Latest Fashions in Skin Disease                                                                                                                123
J.M. Carroll and L.A. Goldsmith

In This Issue
Summaries of articles                                                                                                                                        127

Original Articles
Odorant Receptors and Desensitization Proteins Colocalize in Mammalian Sperm                                      130
L.D. Walensky, A.J. Roskams, R.J. Lefkowitz,  S.H. Snyder*, and  G.V. Ronnett

Regulation of Transcription Functions of the p53 Tumor Suppressor by the 
mdm-2 Oncogene                                                                                                                                              142
J. Chen, J. Lin, and A. J. Levine

Differential Expression of Human Tissue Factor in Normal Mammary Epithelial 
Cells and in Carcinomas                                                                                                                                   153
Z. Chen and R. Sager

Association Between HLA DQB1*03 and Cervical Intra-Epithelial Neoplasia                                             161
K. Odunsi, G. Terry, L. Ho, J. Bell, J. Cuzick, and T.S. Ganesan
Submitted by D.J. Weatherall  

Adenovirus-Mediated Transfer of the Herpes Simplex Virus Thymidine Kinase 
Gene Inhibits Vascular Smooth Muscle Cell Proliferation and Neointima 
Formation Following Balloon Angioplasty of the Rat Carotid Artery                                                            172
M.W. Chang, T. Ohno, D. Gordon, M.M. Lu, G.J. Nabel, E.G. Nabel, and 
J. M. Leiden

Hypoxic Induction of Endothelial Cell Growth Factors in Retinal Cells:                                                       182 
Identification and Characterization of Vascular Endothelial Growth Factor 
(VEGF) as the Mitogen
D.T. Shima, A.P. Adamis, N. Ferrara, K-T. Yeo, T.-K. Yeo, R. Allende, 
J. Folkman, and P. D'Amore

Genomic Organization and Sequence of the Human Natural Resistance                                                       194 
Associated Macrophage Protein (NRAMP) Gene: Identification and Mapping 
of a Promoter Region Polymorphism
J.M. Blackwell, C.H. Barton, J.K. White, S. Searle, A.-M. Baker, H. Williams, 
and M.-A. Shaw
Submitted by D.K. Peters 

Expression Cloning of cDNAs that Render Cancer Cells Resistant to Pseudomonas                                   206 
and Diphtheria Toxin and Immunotoxins
U. Brinkmann, E. Brinkmann and I. Pastan

Nuclear Localization signal of HIV-1 as a Novel Target for Therapeutic                                                       217
L. Dubrovsky, P. Ulrich, C.M. Feldherr, G.J. Nuovo, K.R. Manogue, A.Cerami, 
and M. Bukrinsky

Molecular Medicine Database                                                                                                                      231

Molecular Medicine Calendar                                                                                                                      234

Instructions to Authors                                                                                                                                  236
*Underlining denotes contributing editor.

Molecular Medicine



March 1995

A Molecular Medicine Database                                                                                                                      239 
K.S. Warren

Obituary                                                                                                                                                          241

In This Issue
Summaries of articles                                                                                                                                        242

Original Articles
Autoantibodies to Neuronal Glutamate Receptors in Patients with Paraneoplastic                                       245 
Neurodegenerative Syndrome Enhance Receptor Activation  
L.C. Gahring, R.E. Twyman, J.E. Greenlee, and S.W. Rogers
Submitted by M.R. Capecchi*

An Inhibitor of Macrophage Arginine Transport and Nitric Oxide Production                                             254 
(CNI-1493) Prevents Acute Inflammation and Endotoxin Lethality  
M. Bianchi, P. Ulrich, O. Bloom, M. Meistrell III, G.A. Zimmerman, 
H. Schmidtmayerova, M. Bukrinsky, T. Donnelley, R. Bucala, B. Sherry, 
K.R. Manogue, A.J. Tortolani, A. Cerami, and K.J. Tracey

Nramp Transfection Transfers Ity/Lsh/Bcg-related Pleiotropic Effects on                                                      267
Macrophage Activation: Influence on Oxidative Burst and Nitric Oxide Pathways  
C.H. Barton, S.H. Whitehead, and J.M. Blackwell
Submitted by K.S. Warren

Construction of a Novel Bifunctional Biogenic Amine Receptor by Two Point                                             280 
Mutations of the H2-Histamine Receptor 
J. DelValle, I. Gantz, L. Wang, Y.J. Guo, G. Munzert, T. Tashiro, Y. Konda, 
and T. Yamada

Restricted Usage of T Cell Receptor Va/Ja Gene Segments with Different                                                   287
Nucleotide but Identical Amino Acid Sequences in HLA-DR3+ Sarcoidosis 
J. Grunewald, T. Hultman, A. Bucht, A. Eklund, and H. Wigzell

Hemoglobin Switching in Humans is Accompanied by Changes in the Ratio of                                           297 
the Transcription Factors GATA-1 and SP1 
E.R. Bacon, N. Dalyot, D. Filon, L. Schreiber, E.A. Rachmilewitz, and 
A. Oppenheim. Submitted by S.H. Orkin

Cell Type-Dependent Modulation of the Dominant Negative Action of Human                                            306 
Mutant Thyroid Hormone b1 Receptors 
R. Wong, X. Zhu, M.A. Pineda, S. Cheng, and B. Weintraub
Submitted by I. Pastan

Failure of Aglucerase Infused into Gaucher Disease Patients to Localize in                                                  320 
Marrow Macrophages 
E. Beutler, W. Kuhl, and L.M. Vaughan

Immunogenicity and In Vivo Efficacy of Recombinant Plasmodium Falciparum                                         325
Merozoite Surface Protein-1 in Aotus Monkeys  
S. Kumar, A. Yadava, D.B. Keister, J.H. Tian, M. Ohl, K.A. Perdue-Greenfield, 
L.H. Miller, and D. C. Kaslow

Molecular Medicine Database                                                                                                                      333

Molecular Medicine Calendar                                                                                                                      337

Instructions to Authors                                                                                                                                  339
* Underlining denotes contributing editor.

Molecular Medicine


May 1995

The McCarty Award in Molecular Medicine                                                                                                   341
A. Cerami

Series: Classics in Molecular Medicine
Transforming Biology                                                                                                                                       342
M. McCarty

Avery OT, MacLeod CM, McCarty M.  (1944)  STUDIES ON THE CHEMICAL NATURE OF 

Series: Molecular Medicine Institutions
The Institute of Molecular Medicine, University of Oxford                                                                            366
D. Weatherall

The MD PhD Physician Scientist - Endangered Species or the Next Generation?                                         369
G.J. Nabel

In This Issue
Summaries of Articles                                                                                                                                       371                                                                

Original Articles
Normal and Expanded Huntington's Disease Gene Alleles Produce                                                              374 
Distinguishable Proteins Due to Translation Across the CAG Repeat
F. Persichetti, C.M. Ambrose, P. Ge, S.M. McNeil, J. Srinidhi, M.A. Anderson,
B. Jenkins, G.T. Barnes, M.P. Duyao, L. Kanaley, N.S. Wexler, R.H. Myers, 
E.D. Bird, J.-P. Vonsattel, M.E. MacDonald, and J.F. Gusella
Submitted by S.H. Orkin*

Thalidomide Treatment Reduces Tumor Necrosis Factor a Production and                                                  384 
Enhances Weight Gain in Patients With Pulmonary Tuberculosis
J.M. Tramontana, U. Utaipat, A. Molloy, P. Akarasewi, M. Burroughs, 
S. Makonakawkeyoon, B. Johnson, J.D. Klausner, W. Rom, and G. Kaplan
Submitted by B.R. Bloom

Clozapine: Selective Labeling of Sites Resembling 5-HT6 Serotonin Receptors May                                    398
Reflect Psychoactive Profile
C.E. Glatt, A.M. Snowman, D.R. Sibley, and S.H. Snyder
Antiviral Drugs from the Nucleoside Analogue Family Block Volume-Activated                                         407 
Chloride Channels
M. Gschwentner, A. Susanna, E. W”ll, M. Ritter, U.O. Nagl, A. Schmarda,
A. Laich, G.M. Pinggera, H. Ellemunter, H. Huemer, P. Deetjen and M. Paulmichl
Submitted by K.S. Warren

The Tissue Inhibitor of Metalloproteinases-3 Gene in Breast Carcinoma:                                                     418 
Identification of Multiple Polyadenylation Sites and of a Stromal Pattern 
of Expression
J.A. Byrne, C. Tomasetto, N. Rouyer, J.-P. Bellocq, M.-C. Rio, and P. Basset
Submitted by P. Chambon

LPS and Taxol Activate Lyn Kinase Autophosphorylation in Lpsn, but Not in                                             428
Lpsd, Macrophages
B.E. Henricson, J.M. Carboni, A.L. Burkhardt, and S.N. Vogel
Submitted by A. Cerami

The MarR Repressor of the Multiple Antibiotic Resistance (mar) Operon in                                                436
Escherichia coli: Prototypic Member of a Family of Bacterial Regulatory 
Proteins Involved in Sensing Phenolic Compounds 
M.C. Sulavik, L.F. Gambino, P.F. Miller
Submitted by P. Cuatrecasas

Advanced Glycation Endproducts Promote Adhesion Molecule (VCAM-1, ICAM-1)                                 447
Expression and Atheroma Formation in Normal Rabbits
H. Vlassara, H. Fuh, T. Donnelly, and M. Cybulsky
Submitted by K.S.Warren

Expression of the Von Hippel-Lindau Tumor Suppressor Gene, VHL, in Human                                         457
Fetal Kidney and During Mouse Embryogenesis
P.M. Kessler, S.P. Vasavada, R.R. Rackley, F.-M. Duh, F. Latif, M.I. Lerman,
B. Zbar, and B.R.G. Williams
Submitted by R. Sager

Molecular Medicine Database                                                                                                                      467

Molecular Medicine Calendar                                                                                                                      472

Instructions to Authors                                                                                                                                  475

*Underlining denotes contributing editor. Molecular Medicine


July 1995 (In Press)

Series: Molecular Medicine Institutions
Yale s Boyer Center for Molecular Medicine
V.T. Marchesi and A.N. Brady

HIV Accessory Proteins: Emerging Therapeutic Targets
R.H. Miller and N. Sarver

A Role for T Cells in the Pathogenesis of Treatment-Resistant Lyme Arthritis
T. Kamradt, A. Krause, and G.-R. Burmester

In This Issue
Summaries of Articles

Original Articles
Burkitt s Lymphoma is a Malignancy of Mature B Cells Expressing Somatically 
Mutated V Region Genes
U. Klein, G. Klein, B. Ehlin-Henriksson, K. Rajewsky*, and R. Keppers

Taxol-Induced Mitotic Block Triggers Rapid Onset of a p53-Independent 
Apoptotic Pathway
C.M. Woods, J. Zhu, P.A. McQueney, D. Bollag, and E. Lazarides
Submitted by A.J. Levine

Nerve Growth Factor (NGF) Prevents Both Neuroretinal Programmed Cell Death 
and Capillary Pathology in Experimental Diabetes
H.-P. Hammes, H.J. Federoff, and M. Brownlee
Submitted by A. Cerami

Inhibition of Protein Phosphatase 1 Stimulates Secretion of Alzheimer 
Amyloid Precursor Protein
E.F. da Cruz e Silva, O.A.B. da Cruz e Silva, C.T.B.V. Zaia, and P. Greengard

Amyloid Formation in Response to b Cell Stress In Vitro, But Not In Vivo, 
in Islets of Transgenic Mice Expressing Human Islet Amyloid Polypeptide
G. Westermark, M.B. Arora, N. Fox, R. Carroll, S.J. Chan, P. Westermark, 
and D.F. Steiner

Gamma-Delta T Cell Receptor Analysis Supports a Role for HSP 70 Selection of 
Lymphocytes in Multiple Sclerosis Lesions
L. Battistini, M. Salvetti, G. Ristori, M. Falcone, C.S. Raine, and C.F. 
Submitted by B.R. Bloom

Variable Response to a Candidate Cancer Vaccine Antigen: MHC Control of the 
Antibody Response in the Rat to Avian Erythroblastosis Virus (AEV)-Encoded 
Epithelial Growth Factor Receptor (EGF-R) but not AEV-Encoded Thyroid Hormones 
Receptor (Ths-R)
N.Nardi and N.A.Mitchison

Ciliary Neurotrophic Factor (CNTF) Inhibits Brain and Peripheral Tumor 
Necrosis Factor Production and, When Co-Administered With its Soluble 
Receptor, Protects Mice Against Lipopolysaccharide (LPS) Toxicity
F. Benigni, P. Villa, M.T. Demitri, S. Sacco, J.D. Sipe, L. Lagunowich, 
N. Panayotatos, and P. Ghezzi
Submitted by K.S. Warren

Analysis of Families at Risk for Insulin-Dependent Diabetes Reveals that 
HLA Antigens Influence Progression to Clinical Disease
M.C. Honeyman, L.C. Harrison, B. Drummond, P.G. Colman, and B.D. Tait
Submitted by G.J.V. Nossal

Molecular Medicine Database

Molecular Medicine Calendar

Instructions to Authors

*Underlining denotes contributing editor.

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