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To: Multiple recipients of list HUM-MOLGEN <HUM-MOLGEN@NIC.SURFNET.NL>
Subject: NEWS: in Bioscience and Medicine
From: Frank Zollmann <frank.zollmann@stud.uni-rostock.de>
Date: Fri, 20 Sep 1996 16:33:21 +0200
Organization: University of Rostock

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          HUM-MOLGEN News in Bioscience and Medicine
**************************************************************

News in Bioscience and Medicine:
http://www.informatik.uni-rostock.de/HUM-MOLGEN/NewsGen/

HUM-MOLGEN WWW:
http://www.informatik.uni-rostock.de/HUM-MOLGEN/

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Summary of recent postings:
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1  | Human 2D PAGE Databases for Proteome Analysis
2  | 9/18/96: Infectious Diseases Kill 12 Million Children Each Year
3  | The Mouse Atlas Project
4  | Hematology Physicians Discussion List (HEM-Dr)
5  | HotMolecBase
6  | NCHGR-DOE Guidance on Human Subjects Issues in Large-Scale DNA
Sequencing
7  | Biochemistry Online
8  | NIGMS Human Genetic Mutant Cell Repository catalog
9  | GENETIC VARIANTS OF THE HUMAN OBESITY (OB) GENE ...
10 | How to announce new Internet resources, press releases etc.

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1 | Human 2D PAGE Databases for Proteome Analysis

| WWW:    http://biobase.dk/cgi-bin/celis
| E-mail: jec@biokemi.aau.dk

The following human databases are available: keratinocytes, transitional
cell carcinomas, MRC-5 fibroblats and urine.
You can display protein names and information on specific protein spots
by clicking on the image of the gel representing the 2-D gel map in
which
you are interested. Also, you can search by protein name or organelle or
cellular component.

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2 | 9/18/96: Infectious Diseases Kill 12 Million Children Each Year

| WWW:    http://WWW.IH.JHU.EDU/
| E-mail: RBLACK@PHNET.SPH.JHU.EDU

Full text available at
http://www.informatik.uni-rostock.de/HUM-MOLGEN/NewsGen/

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3 | The Mouse Atlas Project

| WWW:    http://glengoyne.hgu.mrc.ac.uk/

The UK MRC Human Genetics Unit in Edinburgh is currently developing
a digital atlas of mouse development and database to be a resource
for spatially mapped data such as in situ gene expression and cell
lineage. The project is in collaboration with the Department of Anatomy,
University of Edinburgh, the Jackson Laboratory, USA and a European
Science
Foundation Network.

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4 | Hematology Physicians Discussion List (HEM-Dr)

| E-mail: romeo-mandanas@uokhsc.edu

HEM-Dr (Hematology Physicians Discussion List) is a private mailing list
designed mainly for physicians and the discussion of issues in
hematology
or blood, bone marrow or lymph gland disorders. Medical doctors, PhDs,
and
scientists working in the field of hematology or hematopathology as well
as
referring physicians are invited to participate in this discussion list.
Patients
and their loved ones who are seeking support group or hematology-related
information are referred to either of two separate lists called HEM-ONC
or
MPD-NET.

Hematology deals with the study of both benign disorders of the blood,
bone marrow and lymph glands as well as malignant diseases such as
leukemias
and lymphomas. HEM-Dr allows a private network of parties involved in
hematology
to conduct rapid exchange of informal discussions on various issues to
ultimately
foster better patient care and outcome.

To join the list or contact the listowners, write to:

HEM-Dr-request@sjuvm.stjohns.edu

Romeo A. Mandanas M.D.
HEM-Dr Listowner
romeo-mandanas@uokhsc.edu

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5 | HotMolecBase

| WWW:    http://bioinformatics.weizmann.ac.il/hotmolecbase/
| E-mail: lvrebhan@bioinformatics.weizmann.ac.il
Reply to [the Author]

Looking for molecules playing a central role in the pathogenesis of the
disease
you are interested in? Or are you searching for useful monoclonal
antibodies
directed against a certain antigen; for the cellular function(s), or the
expression pattern of a certain protein? Then HotMolecBase, the database
about
medically interesting molecules, may be an interesting site to visit. To
see what
it's all about, have a look into the typical entry, or try the
simple-to-use
search engine. If you cannot find the information you're searching for,
contact the author, and send him some words describing your problems,
so that this ever evolving web service may adjust to your needs.

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6 | NCHGR-DOE Guidance on Human Subjects Issues in Large-Scale DNA
Sequencing

| WWW:
http://www.ornl.gov/TechResources/Human_Genome/archive/nchgrdoe.html

The Human Genome Project (HGP) is now entering into large-scale DNA
sequencing.
To meet its complete sequencing goal, it will be necessary to recruit
volunteers willing to contribute their DNA for this purpose. The
guidance is
intended to address ethical issues that must be considered in designing
strategies for recruitment and protection of DNA donors for large-scale
sequencing.

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7 | Biochemistry Online

| WWW:    http://www.arach-net.com/~jlyon/biochem/index.html
| E-mail: vtga@uhura.cc.rochester.edu

Announcing Biochemistry Online, an internet based journal. Can be
accessed at
http://www.arach-net.com/~jlyon/biochem/index.html
The third issue can be viewed at the following site :
http://www.arach-net.com/~jlyon/biochem/issue3/index.html

Also, calling for papers for publication in the future issues of the
journal.

Querries can be addressed to either Justin Lyon at
mailto:jlyon@trib.net or to Vineet Gupta at
vtga@uhura.cc.rochester.edu

Thanx,
Vineet Gupta
Editor Biochemistry Online

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8 | NIGMS Human Genetic Mutant Cell Repository catalog

| WWW Home Page
| E-mail: jbeck@umdnj.edu

A World Wide Web version of the NIGMS Human Genetic Mutant Cell
Repository
catalog is now available (http://arginine.umdnj.edu/coriell/nigms.htm).
The Repository has human cell cultures available in the following
categories:
inherited metabolic disorders, biochemically mutant cell cultures with
characterized mutations, well-characterized chromosomally aberrant cell
cultures, CEPH Reference Families, a human diversity collection, and
human/rodent somatic cell hybrid mapping panels. Menus are provided to
allow
users to search for cell cultures or DNA samples in a variety of ways,
including Repository number, MIM number, disease description, as well as
chromosome abnormality and number.
Chromosome ideograms are provided for human/rodent somatic cell hybrids.

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9 | GENETIC VARIANTS OF THE HUMAN OBESITY (OB) GENE ...

| E-mail: LICINIO@NIH.GOV

PRESS RELEASE

GENETIC VARIANTS OF THE HUMAN OBESITY (OB) GENE: ASSOCIATION
WITH BODY MASS INDEX IN YOUNG WOMEN, PSYCHIATRIC SYMPTOMS,
AND INTERACTION WITH THE DOPAMINE D2 RECEPTOR (DRD2) GENE.

DE Comings, R Gade, J MacMurray, D Muhleman, P Johnson, R Verde, WR
Peters.
City of Hope National Medical Center, Duarte, California, USA and Loma
Linda
University, Loma Linda, California, USA
Molecular Psychiatry 1996; vol. 1, issue 4 (September 1996).

In a study reported in the current issue of the journal Molecular
Psychiatry, researchers at City of Hope National Medical Center, Duarte,
California, USA and Loma Linda University, Loma Linda, California, USA
examined a complex, genetically variable region (polymorphism)
close to the human obesity (OB) gene and found that certain genetic
variants next to the human OB gene are associated with obesity in young
women, but not young men. They also found that the genetic variants at
the
OB gene were also associated in these women with depression and anxiety,
two of the behaviors most often associated with obesity. The results
suggest
the depression was a direct result of the OB gene variants and not just
secondary to the obesity. The cloning and sequencing of the mouse and
the
human obesity (OB) genes have been greeted with enormous excitement.
When mice
have a defective OB gene on both chromosomes, they are very obese and
treatment
with leptin, the product of the OB gene, causes rapid weight loss. This
led to
the hope that obese humans also had a defective OB gene, and treatment
with
leptin would also cause weight loss. However, many subsequent studies
have
shown that obese humans have too much leptin, not too little, and no
mutations
of the OB gene itself were found.
Thus, the OB gene - leptin story is far more complex than originally
thought.
In 1993 DE Comings and colleagues found that variants of the dopamine D2
receptor gene (DRD2), originally reported by K Blum and EP Noble as
being
associated with severe alcoholism, were also associated with obesity.
Blum and
Noble confirmed this association, and both groups found an association
between
the DRD2 gene and drug addiction. All three of these substances
(alcohol, drugs
and food), stimulate the reward pathways of the brain. Now Comings and
coworkers
found that the OB and DRD2 genes were additive in their effect on
obesity in young
women. Both genes combined accounted for 22% of the obesity in young
women.
These results are consistent with obesity being the result of many
different genes
(polygenic), with a greater involvement of genetic factors in women and
younger
subjects, and suggest that variants of the OB gene are causally involved
not only
with human obesity but with its associated behavioral disorders. An
independent
commentary by Dr. Gerald J. LaHoste
(University of California at Irvine, USA; FAX: + 1 714 824-2447; phone:
+1 714 824-4722;
e-mail: glahoste@parker.bio.uci.edu) also appears in the current issue
of Molecular Psychiatry.
EMBARGOED UNTIL SEPTEMBER 15, 1996

This article will be published in the September issue of Molecular
Psychiatry,
a peer-reviewed journal published by Stockton Press/Macmillan Press.
Editor: Julio Licinio, MD - editorial assistant: Rachel Lisman
NIH, Bldg. 10/2D46, 10 Center Drive, Bethesda, MD 20892-1284, USA
phone: (301) 496-6885; FAX: +1 (301) 402-1561; e-mail: licinio@nih.gov
Publisher: Marija Vukovojac, phone and FAX: +44 1483 892119
e-mail: 100743.2265@CompuServe.COM

For information on the scientific aspects of the article please contact
the author:
Dr. David E. Comings, Department of Medical Genetics, City of Hope
National
Medical Center, 1500 East Duarte Road, Duarte, CA 91010-0269, USA
phone: +1 (818) 359-8111; FAX: +1 (818) 301-8980

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10 | How to announce new Internet resources, press releases etc.

You can announce (free) new Internet resources, press releases etc. at

http://www.informatik.uni-rostock.de/cgi-bin/HMB/NewsGen/vw3news?postF

For other announcements please take a look at

http://www.informatik.uni-rostock.de/HUM-MOLGEN/hum/submit.html

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in any way for the contents, or part of the contents, or even phrases of
messages appearing on HUM-MOLGEN or it's TOPICs.
Responsibility for the (contents of) messages solely rests with the
sender of these messages.

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