| 2008-05-01 |
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A Rogue Neighbourhood
Gene expression changes in the tissue microenvironment in which a tumour arises can be used to predict outcome in patients with breast cancer.
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Focus On Natural Killer Cells
A series of articles explore the behaviour of the enigmatic lymphocytes (natural killer - NK - cells), and reflect on their transition from outcasts of mainstream immunology to prominent players in innate immunity.
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Sequencing Sheds Light On The Cancer Genome
The rearrangement of genomes in people with lung cancer can be identified using an approach called 'massively parallel sequencing.'
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Inflammatory Bowel Diseases Share Genetic Risk Factors
Several genetic risk variants are identified for the common inflammatory bowel disease ulcerative colitis.
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Breast Cancer Risk Variants
Two common genetic variants on chromosome 5 increase susceptibility to certain types of breast cancer breast cancer.
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Why We Are All Different
A paper takes a close look at the larger variations within human DNA and their potential origins and evolutionary history.
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Test-Tube Recipe Makes Functioning Heart Cells
A Canadian, US and British research team has successfully grown three types of human heart cells from cultures derived from embryonic stem cells.
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Sequencing Gets Personal
Two months and less than $1 million is all it takes to sequence an individual genome.
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Helping The Immune System
Researchers identify a protein involved in blood circulation in tumours and demonstrate that deleting it opens up the tumour to the immune system.
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| 2008-04-28 |
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Molecular Basis for Neurodegeneration in Ataxia telangiectasia
Ataxia telangiectasia (ATM) gene has been found to regulate the cell cycle in neurons, so cell cycle inhibitors may have therapeutic potential in A-T
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Researchers Make New Finding about How Memory is Stored
Localized protein destruction regulates nerve cell connections
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| 2008-04-17 |
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'What' And 'Where' In Auditory Cortex
A study published online reports conclusive evidence for auditory brain areas being segregated by whether they contribute to recognizing an object -- the 'what' pathway -- or processing where an object is located -- the 'where' pathway.
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Decisions Occur Before Awareness
Activity in certain areas of the brain signals what choice people are going to make up to ten seconds before they become consciously aware of their decision.
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Host-To-Graft Disease Spread In Parkinson Disease?
Cell transplants have long been proposed as a possible therapy for Parkinson disease, but a series of reports suggest that the pathology may spread from the host to the transplants.
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Common Genetic Variants Influencing Adult Height
Scientists have discovered dozens of common genetic variants influencing adult human height, according to three studies published online.
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Arsenic Action On Leukaemia
Scientists have identified the mechanism by which compounds of arsenic can actually have therapeutic properties when used to treat certain types of cancer.
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p53 Hampers Energy Metabolism In Cancer Cells
The tumour suppressor p53 can limit tumour development by inhibiting aerobic glycolysis.
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Pinpointing Lymphoblastic Leukaemia Lesions
Scientists identify another mutant protein that causes bone marrow cells to multiply uncontrollably in ALL (acute lymphoblastic leukaemia) patients.
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| 2008-04-03 |
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How Synaptic Activity Protects Neurons
Scientists have identified a key signalling pathway that could protect areas of the brain at risk of damage from ageing and neurodegenerative diseases.
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A New Therapy Of Cystic Fibrosis
A potential treatment for cystic fibrosis has been identified in mice.
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The Best Of Both Worlds
The creation of a combined positron emission tomography (PET) and magnetic resonance imaging (MRI) scanner is reported online.
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Therapeutic Cloning Treats Neurodegenerative Disease
Therapeutic cloning can be used to treat Parkinson's disease in mice.
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Colorectal Cancer Risk Variants
Three new variants are associated with increased risk of colorectal cancer.
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New Genetic Risk Factors For Type 2 Diabetes
At least six regions of the genome harbor variants that predispose to type 2 diabetes.
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RNA Trojan Horses Zero In On Liver Cirrhosis
Using vitamin A to target the cells that cause liver cirrhosis may improve the treatment of the disease.
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Route To Thwarting Skin Cancer
A paper has identified how the cells in epithelial tumours signal to one another in order to keep the population of rogue stem cells topped up.
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Moving In On Drug Resistance
A paper in reveals a mechanism of how antifungal drugs have the unwanted effect of boosting the fungus' arsenal of pumps used to fight them off.
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Smoking Receptors Mirror Lung Cancer Genes
A region on chromosome 15 that hosts three nicotine receptor subunit genes is associated with risk of lung cancer.
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MicroRNA Silencing In Non-Human Primates
Researchers have effectively silenced microRNAs (miRNAs) in monkeys for the first time, targeting a liver-specific miRNA and reducing blood cholesterol as a result.
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Genetic Blindness Treatments Emphasize Immune Role
A promising treatment for age-related macular degeneration - responsible for up to 50 million cases of blindness worldwide - works by a more general mechanism than had previously been thought.
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Novel Fullerene Shows Potential For Secondary Progressive Multiple Sclerosis
A water-soluble fullerene-NMDA receptor antagonist hybrid prevented disease progression in an animal model, by protecting against axonal loss and demyelination.
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| 2008-03-30 |
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A Novel Search Engine for Disease Genes
Rapidly Identifying Genes Associated with Hereditary Disease and Cancer
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| 2008-03-26 |
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DNMT1: a direct transcriptional repressor?
Recent work shows an unexpected effect for a well known methyltranferase.
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| 2008-03-20 |
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Gene Therapy Alleviates Neurodegenerative Disease In Mice
Mice with neurodegenerative diseases have been successfully treated with gene therapy.
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Adapting Brain And Behaviour To Match The Environment
Zones in a specific brain area change size depending on whether rats experience a calm or stressful environment.
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Finding Allele-Specific Gene Expression
Scientists have developed a genome-wide technique to identify whether a person is expressing genetic information from their mother or father.
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Oncogenic microRNA
Scientists have discovered how a particular cluster of short strings of genetic material called microRNAs promotes lymphoma development.
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Damage Limitation
A key regulator of the DNA damage response is directly activated by the transcription factor FOXO3a - a protein known to regulate the cell cycle and cell death.
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'Lifeline' For Tumour Cells Can Be Cut
Researchers studying cancers in mice have identified a protein that is crucial for tumour survival, raising the prospect that new cancer therapies might halt tumours in their tracks by targeting this molecule.
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Fresh Detective Approach Finds New Obesity Genes
By turning the conventional method of hunting for disease genes on its head, a team of geneticists has discovered three new genes linked to obesity.
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Missing Cells To Blame In Job's Syndrome
New research by immunologists on the rare immune disease called Job's syndrome shows that sufferers lack a specific type of white blood cell, leaving them open to repeated attack by certain bacterial and fungal pathogens.
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Subverting A Metabolic Pathway For Tumour Growth
Two research papers shed further light on the mechanisms underlying the switch in the way glucose is metabolized by tumour cells.
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'Crime Boss' Gene Controls Aggressive Breast Tumours
Geneticists have identified a gene that promotes aggressive breast cancer by altering the behaviour of more than 1,000 other genes within tumour cells.
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| 2008-03-18 |
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New Insight into the Genetics of Brain Tumor Formation
Gene mutated in neural crest tumors normally helps promote apoptosis
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Role for MicroRNAs in Limb Regeneration
miRNA regulation in the model organism zebrafish impacts tissue regeneration
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| 2008-03-17 |
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Growing old together: Yeast, worms, and people may age by similar mechanisms
Genes conserved across evolutionarily diverse organisms may be important for human aging
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| 2008-03-06 |
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Household Allergens Make Skin Vulnerable To Eczema
Dust mite and cockroach allergens aggravate the symptoms of eczema and similar diseases by disrupting skin barrier function.
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Autoimmunity Affected By More Than A Defective Immune System
Research suggests that autoimmunity is linked to defective developmental biology as well as a defective immune system.
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Chemical Treatment Of Neurons Makes Them Light Sensitive
A chemical treatment that makes neurons light responsive is described.
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Bone Marrow Nurturers
Researchers have identified a new cell residing in bone marrow that provides an essential survival factor for antibody-producing B cells.
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