Royal Pharmaceutical Society of Great Britain, Cambridge
Sunday 17 - Thursday 21 May 2009
Sunday 17 May
17.00 Registration
18.30 Welcome drinks reception
19.15 Course dinner Monday 18 May
08:15 Introduction and mental contract· What are our expectations· Course layout & course material & evaluation form
08:30 Pharmacodynamic (Equilibrium)· Review of Steady-state models· Steady-state models· Kinetics of drug action· Initial parameter estimates· Design issues and Case Studies
09:30 Coffee/tea
09:45 Pharmacodynamic (Distributional delays) · Steady-state models vs. time delay· Basic concepts on distributional delays· Modelling QT-data with link models· Initial parameter estimates· Design issues and Case Studies
10:30 Hands-on session 1· Inst. equil. models, steady-state, log-linear, sigmoidal · Incomplete datasets
12:00 Lunch
13:00 – 16.30 Hands-on session 2· Modeling EEG-data with link models· Modeling QT- & MAPD data with link models· Design issues and Case Studies
14:30 Coffee/tea
16:30 Numerical Grammar
18:00 Course dinner
19:00 Evening exercise on your own Tuesday 19 May
08:30 Pharmacodynamics (Turnover A) · Residual questions from Day 1 · Turnover concepts I - ‘The Gang of four’· Constant and variable baseline· Comparing link- and turnover models· Initial estimates· Design issues and Case Studies
09:30 Coffee/tea
09:45 Hands-on session 3· Turnover models I-IV · Turnover model I of blood clotting data
12:00 Lunch
13:00 Hands-on 3 cont.· Collapsing hysteresis loops· Design issues and Case Studies
14:45 Coffee/tea
15:00 Group exercise – FTIM compound selection· Compound evaluations· Dose prediction, dose nomogram· Assessment of safety margin
17:00 Wrap-up & Project exercise
18:00 Course dinner
19:00 QTc lecture Wednesday 20 May
08:30 Pharmacodynamics (Turnover B) · Residual questions from Day 2 · The thought process· Peak shifts· Limited production and loss· Synergy by means of turnover models· Transduction models· Irreversible response· Initial parameter estimates
09:30 Coffee/tea
09:45 Hands-on session 4 · Turnover models I-IV · Comparing IRP and Link· Design issues and Case Studies
12:00 Lunch
13:00 Hands-on session 4 cont.· Turnover models I-IV cont.· Fitting multiple dose PD data
15:00 Coffee/tea
15:15 Introduction and Group exercises · Group Exercise I· Group Exercise II· Group Exercise III
17:00 Wrap-up & Group exercise
18:30 Course dinner
19.45 Social programme Thursday 21 May
08:30 Pharmacodynamics (Adaptation) · Residual questions from Day 3· Models for adaptation· Tolerance and rebound· Feed-back systems · Oscillating baselines· Initial parameter estimates
09:30 – 12.00 Hands-on session 5 · Turnover models I-IV continue· Synergy· Transduction models· Irreversible response· Design issues and Case Studies
10:00 Coffee/tea
12:00 Lunch
13:00 Hands-on session 5 cont.· Feedback· Analyzing PD data from Phase I study
14:00 Experimental Design· Own datasets· Synergy
15:00 Summary
15.15 Close of course
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