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Variants Associated with Pediatric Allergic Disorder
Genetic variants at chromosome 5q22 are associated with pediatric eosinophilic esophagitis (EoE) - a type of allergic disorder often triggered by food allergies.
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Mutations in PHF6 Found in T-Cell Leukemia
The X chromosome gene PHF6 is frequently mutated in a certain type of leukemia
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Genetic Risk Variant for Urinary Bladder Cancer
Another genetic variant associated with risk of urinary bladder cancer is reported in a study
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Antibody Has Therapeutic Effect on Mice with ALS
A biological treatment targeting the protein CD40L has a therapeutic effect on mice with amyotrophic lateral sclerosis (ALS).
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Regulating P53 Activity in Cancer Cells
The protein BRD7 activates p53 and could therefore suppress the development of cancerous tumours.
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Anti-RNA Therapy Counters Breast Cancer Spread
A new type of therapy that prevents the metastatic spread of breast cancer in a mouse model of breast cancer is presented
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Mitochondrial DNA Diversity
A study of normal and cancerous human cells shows that Mitochondrial DNA is more heterogeneous than was thought.
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The Power of RNA Sequencing
RNA sequencing is a powerful tool for teasing apart the genetic mechanisms that underpin variation in gene expression.
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‘Pro-Ageing' Therapy for Cancer?
The discovery of a signalling pathway that forces cancerous cells to age could aid the development of a general approach for cancer therapy.
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Niche Genetics Influence Leukaemia
Certain blood cancers can be triggered by genetic changes in the blood cells' microenvironment.
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Molecular Biology: Clinical Promise for RNA Interference
The first proof-of-principle study showing that the gene-silencing technique RNA interference (RNAi) can indeed lower levels of gene expression in humans is revealed.
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Chemoprevention Cocktail for Colon Cancer
Treating premalignant colorectal cells with a protein cocktail that 'persuades' them to commit cell suicide may prove a useful method of cancer chemoprevention.
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